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Unlike oral B12, which depends on intrinsic factor and healthy gut absorption, the injection delivers B12 directly into the bloodstream

[3] The proposed mechanism involves B12 altering the gene expression of skin bacteria ( Cutibacterium acnes ), leading to increased inflammatory compounds

22 May 2026 6 min Why do I feel worse after my B12 injection

An ampoule opener may be required for safe opening and handling

Serum B12 reference ranges vary between laboratories, but generally, levels below 148 pmol/L are considered deficient, whilst levels between 148258 pmol/L are regarded as borderline and may warrant further investigation or a trial of treatment, particularly if symptoms are present

[3] Those taking high-dose oral supplements without medical supervision also face increased risk